1. J Int Soc Sports Nutr. 2008 Jan 29;5:3.

Effects of a supplement designed to increase ATP levels on muscle strength, power
output, and endurance.

Herda TJ, Ryan ED, Stout JR, Cramer JT.

Department of Health and Exercise Science, University of Oklahoma, Norman, USA.
tjh@ou.edu

BACKGROUND: The present study examined the acute effects of a nutritional
supplement intended to improve adenosine triphosphate (ATP) concentrations on
vertical jump height, isometric strength of the leg extensors, leg extension
endurance, and forearm flexion endurance.
METHODS: Twenty-four healthy men (mean age +/- SD = 23 +/- 4 yrs, stature = 181
+/- 7 cm, and body mass = 82 +/- 12 kg) volunteered to complete a familiarization
trial plus 2 randomly-ordered experimental trials separated by a 7-day washout
period. Participants received either 6 (body mass < 91 kg) or 8 (body mass >/= 91
kg) tablets of the treatment (TR; 625 mg of adenylpyrophosphoric acid and calcium
pyruvate, 350.8 mg of cordyceps sinensis extract and yohimbine hydrochloride) or 
placebo (PL; 980 mg of microcrystalline cellulose) 1 hour prior to the following 
tests: countermovement vertical jump (CVJ), forearm flexion repetitions to
exhaustion, isometric maximal voluntary contractions (MVCs) of the leg extensors,
and a 50-repetition maximal concentric isokinetic leg extension endurance test.
RESULTS: There were no differences between the TR and PL trials for CVJ height (P
> 0.05), isometric MVC peak torque (P > 0.05), maximal concentric isokinetic peak
torque (P > 0.05), percent decline during the leg extension endurance tests (P > 
0.05), or repetitions to exhaustion during the forearm flexion endurance tests (P
> 0.05).
CONCLUSION: These findings indicated no improvements in the measured variables as
a result of ingesting this nutritional supplement. Future studies should examine 
whether chronic supplementation or a loading period is necessary to observe any
ergogenic effects of this supplement.

PMCID: PMC2253504
PMID: 18230170  [PubMed]